Transmission of a fully functional human neocentromere through three generations

American Journal of Human Genetics

Volumn 64, Issue 5, 1999, Pages 1440-1444

  Tyler Smith, Chris ^e   Gimelli, Giorgio ^e   Giglio, Sabrina ^a   Floridia, Giovanna ^a   Pandya, Arpita ^e   Terzoli, Gianluigi ^b   Warburton, Peter E ^e   Earnshaw, William C ^e   Zuffardi, Orsetta ^b,c,d  

^a UNIVERSITY OF PAVIA   (Italy)

^b REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^c SAN RAFFAELE HOSPITAL   (Italy)

^d Biologia Generale e Genetica Medica   (Italy)

^e NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CHROMOSOME ANALYSIS; CHROMOSOME DELETION; CHROMOSOME LOSS; FEMALE; GENE ACTIVATION; GENE FUNCTION; GENE LOCUS; GENE SILENCING; HUMAN; MALE; MEIOSIS; PRIORITY JOURNAL; Y CHROMOSOME;

POMACANTHUS MACULOSUS; RAPHIA FRATER;

EID: 0000187034     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/302380     Document Type: Article

References (21)

1. Bukvic N, Susca F, Gentile M, Tangari E, Ianniruberto A, Guanti G (1996) An unusual dicentric Y chromosome with functional centromere with no detectable alpha satellite. Hum Genet 97:453-456
2. Casanova M, Leroy P, Boucekkine C, Weissenbach J, Bishop C, Fellous M, Purrello M, et al (1985) A human Y-linked DNA polymorphism and its potential for estimating genetic and evolutionary distance. Science 230:1403-1406
3. Choo KHA (1997) Centromere DNA dynamics: latent centromeres and neocentromere formation. Am J Hum Genet 61:1225-1233
4. Csink AK, Henikoff S (1998) Something from nothing: the evolution and utility of satellite repeats. Trends Genet 14:200-204
5. du Sart D, Cancilla MR, Earle E, Mao JI, Saffery R, Tainton KM, Kalitsis P, et al (1997) A functional neo-centromere formed through activation of a latent human centromere and consisting of non-alpha-satellite DNA. Nat Genet 16:144-153
6. Earnshaw WC, Ratrie H, Stetten G (1989) Visualization of centromere proteins CENP-B and CENP-C on a stable dicentric chromosome in cytological spreads. Chromosoma 98:1-12
7. Earnshaw WC, Sullivan KF, Machlin PS, Cooke CA, Kaiser DA, Pollard TD, Rothfield NE, et al (1987) Molecular cloning of cDNA for CENP-B, the major human centromere autoantigen. J Cell Biol 104:817-829
8. Fisher AM, Al-Gazali L, Pramathan T, Quaife R, Cockwell AE, Barber JC, Earnshaw WC, et al (1997) Centromeric inactivation in a dicentric human Y;21 translocation chromosome. Chromosoma 106:188-206
9. Haaf T, Schmid M (1989) Centromeric association and non- random distribution of centromeres in human tumour cells. Hum Genet 81:137-143
10. Karpen GH, Allshire RC (1997) The case for epigenetic effects on centromere identity and function. Trends Genet 13:489-496
11. Kwok C (1996) Mutation analysis of the 2 kb 5′ to SRY in XY females and XY intersex subjects. J Med Genet 33:465-468
12. Mathias N, Bayes M, Tyler-Smith C (1994) Highly informative compound haplotypes for the human Y chromosome. Hum Mol Genet 3:115-123
13. Palmer DK, O'Day K, Margolis RL (1990) The centromere specific histone CENP-A is selectively retained in discrete foci in mammalian sperm nuclei. Chromosoma 100:32-36
14. Rossi E, Faiella A, Zeviani M, Labeit S, Floridia G, Brunelli S, Cammarata M, et al (1994) Order of six loci at 2q24-q31 and orientation of the HOX locus. Genomics 24:34-40
15. Saitoh H, Tomkiel J, Cooke CA, Ratrie HR III, Maurer M, Rothfield NF, Earnshaw WC (1992) CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate. Cell 70:115-125
16. Tyler-Smith C, Corish P, Burns E (1998) Neocentromeres, the Y chromosome and centromere evolution. Chromosome Res 6:65-67
17. Tyler-Smith C, Oakey RJ, Larin Z, Fisher RB, Crocker M, Affara NA, Ferguson-Smith MA, et al (1993) Localization of DNA sequences required for human centromere function through an analysis of rearranged Y chromosomes. Nat Genet 5:368-375
18. Vafa O, Sullivan KF (1997) Chromatin containing CENP-A and a-satellite DNA is a major component of the inner kinetochore plate. Curr Biol 7:897-900
19. Warburton PE, Cooke CA, Bourassa S, Vafa O, Sullivan BA, Stetten G, Gimelli G, et al (1997) Immunolocalization of CENP-A suggests a distinct nucleosome structure at the inner kinetochore plate of active centromeres. Curr Biol 7:901-904
20. Williams BC, Murphy TD, Goldberg ML, Karpen GH (1998) Neocentromere activity of structurally acentric mini-chromosomes in Drosophila. Nat Genet 18:30-37
21. Yen TJ, Li G, Schaar B, Szilak I, Cleveland DW (1992) CENP-E is a putative kinetochore motor that accumulates just prior to mitosis. Nature 359:536-539