Conformational polymorphism in peptidic and nonpeptidic drug molecules

Biopolymers

Volumn 40, Issue 5, 1996, Pages 585-592

  Taylor, Paul ^a   Mikol, Vincent ^b,c   Kallen, Jörg ^b   Burkhard, Peter ^d   Walkinshaw, Malcolm D ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b SANOFI   (France)

^c Preclinical Research   (Switzerland)

^d UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Conformations; Cyclophilin; peptide; Cyclosporin a; Fk506 binding proteins; Fk506, imnumosupressants; Hydrophilic collapse; Immunophilins; Peptidyl prolyl isomerases; Protein; X ray structure

Indexed keywords

CONFORMATIONS; CRYSTAL STRUCTURE; DRUG PRODUCTS; ENZYMES; HYDROGEN BONDS; X RAY CRYSTALLOGRAPHY;

AMIDE BONDS; CYCLOPHILINS; CYCLOSPORINS; HYDROPHILIC COLLAPSE; IMMUNOSUPPRESSANTS; MACROLIDE LIGANDS; PEPTIDYL PROLYL ISOMERASE;

PROTEINS;

CYCLOSPORIN A; TACROLIMUS;

ARTICLE; HYDROGEN BOND; LIGAND BINDING; MOLECULAR INTERACTION; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION;

AMINO ACID ISOMERASES; CARRIER PROTEINS; CYCLOSPORINE; CYCLOSPORINS; DNA-BINDING PROTEINS; HEAT-SHOCK PROTEINS; HYDROGEN BONDING; LIGANDS; MACROLIDES; MOLECULAR CONFORMATION; PEPTIDYLPROLYL ISOMERASE; POLYENES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SIROLIMUS; TACROLIMUS; TACROLIMUS BINDING PROTEINS;

EID: 0000181824     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0282(1996)40:5<585::AID-BIP16>3.0.CO;2-G     Document Type: Article

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