EICESS 92 (European Intergroup Cooperative Ewing's Sarcoma Study) - First results;EICESS 92 (European Intergroup Cooperative Ewing's Sarcoma Study) - Erste ergebnisse

Klinische Padiatrie

Volumn 211, Issue 4, 1999, Pages 276-283

  Paulussen, Michael ^c   Ahrens, S ^d   Braun Munzinger, G ^d   Craft, A W ^d   Dockhorn Dworniczak, B ^d   Dorffel W ^d   Dunst, J ^d   Frohlich B ^d   Gobel U ^d   Haussler M ^d   Klingebiel, T ^d   Koscielniak, E ^d   Mittler, U ^d   Rube C ^d   Winkelmann, W ^d   Voute P A ^a   Zoubek, A ^b   Jurgens H ^d  

^a EMMA CHILDREN S HOSPITAL   (Netherlands)

^b ST ANNA CHILDREN S HOSPITAL   (Austria)

^c UNIVERSITY OF MÜNSTER   (Germany)

^d NONE

Author keywords

Ewing tumors; Outcome; Secondary malignancies; Toxicity; Treatment

Indexed keywords

CYCLOPHOSPHAMIDE; DACTINOMYCIN; DOXORUBICIN; ETOPOSIDE; IFOSFAMIDE; VINCRISTINE;

ARTICLE; BONE MARROW DEPRESSION; CANCER MORTALITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EWING SARCOMA; HUMAN; LUNG METASTASIS; MAJOR CLINICAL STUDY; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; TUMOR LOCALIZATION; TUMOR VOLUME;

EID: 0000106623     PISSN: 03008630     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1043800     Document Type: Article

References (46)

1. 1 Ewing, J.: Diffuse endothelioma of bone. Proc. N. Y. Pathol. Soc. 21 (1921) 17-24
2. 2 Askin, F. B., J. Rosai, R. K. Sibley, L. P. Dehner, W. H. McAlister: Malignant small cell tumor of the thoracopulmonary region in childhood: a distinctive clinicopathologic entity of uncertain histogenesis. Cancer 43 (1979) 2438-2451
3. 3 Kovar, H.: Ewing s sarcoma and peripheral primitive neuroectodermal tumors after their genetic union. Curr. Opin. Oncol. 10 (1998) 334-342
4. 4 Jaffe, N., D. Paed, D. Traggis, S. Salian, J. R. Cassady: Improved outlook for Ewing's sarcoma with combination chemotherapy (vincristine, actinomycin D and cyclophosphamide) and radiation therapy. Cancer 38 (1976) 1925-1930
5. 5 Rosen, G., B. Caparros, C. Mosende, B. McCormick, A. G. Huvos, R. C. Marcove: Curability of Ewing's sarcoma and considerations for future therapeutic trials. Cancer 41 (1978) 888-899
6. 6 Craft, A. W.: Chemotherapy for Ewing's sarcoma. Baill. Clin. One. 1 (1987) 205-221
7. 7 Miser, J. S., T. J. Kinsella, T. J. Triche, M. Tsokos, P. Jarosinski, R. Forquer, R. Wesley, I. Magrath: Ifosfamide with mesna uroprotection and etoposide: an effective regimen in the treatment of recurrent sarcomas and other tumors of children and young adults. J. Clin. Oncol. 5 (1987) 1191-1198
8. 8 Jürgens, H., V. Bier, J. Dunst, D. Harms, A. Jobke, R. Kotz, J. Kühl, S. Müller-Weihrich, J. Ritter, M. Salzer-Kuntschik, R. Sauer, W. Sternschulte, J. Treuner, P. A. Voûte, P. Weinel, W. Winkelmann, H. Winkler, U. Göbel: [The German Society of Pediatric Oncology Cooperative Ewing Sarcoma Studies CESS 81/86: report after 61/2 years] Die GPO cooperativen Ewing-Sarkom Studien CESS 81/86: Bericht nach 61/2 Jahren. Klin. Pädiatr. 200 (1988) 243-252
9. 9 Jürgens, H., V. Exner, H. Gadner, D. Harms, J. Michaelis, R. Sauer, J. Treuner, T. Voute, W. Winkelmann, K. Winkler, U. Göbel: Multidisciplinary treatment of primary Ewing's sarcoma of bone. A 6-year experience of a European Cooperative Trial. Cancer 61 (1988) 23-32
10. 10 Kinsella, T. J., J. S. Miser, B. Waller, D. Venzon, E. Glatstein, L. Weaver McClure, M. E. Horowitz: Long-term follow-up of Ewing's sarcoma of bone treated with combined modality therapy. Int. J. Radiat. Oncol. Biol. Phys. 20 (1991) 389-395
11. 11 Grier, H., M. Krailo, M. Link, N. Tarbell, C. Fryer, D. Pritchard, M. Gebhardt, P. Dickman, E. Pearlman, P. Meyers, S. Moore, A. Rausen, T. Vietti, J. Miser: Improved outcome in non-metastatic Ewing's Sarcoma and PNET of bone with the addition of ifosfamide and etoposide to vincristine, adriamycin, cyclophosphamid, and actinomycin-D. A CCG and POG report. Proc. ASCO 13 (1993) 421-421 (Abstr.)
12. 12 Ahrens, S., C. Hoffmann, S. Jabar, G. Braun-Munzinger, M. Paulussen, J. Dunst, Ch. Rübe, W. Winkelmann, A. Heinecke, U. Göbel, K. Winkler, D. Harms, J. Treuner, H. Jürgens:Evaluation of prognostic factors in a tumor volume adapted treatment strategy for localized Ewing's sarcoma of bone: The CESS 86 experience. Medical and Pediatric Oncology 32 (1999) 186-195
13. 13 Vietti, T. J., E. A. Gehan, M. E. Nesbit, Jr., E. O. Burgert, Jr., M. Pilepich, M. Tefft, J. Kissane, D. J. Pritchard: Multimodal therapy in metastatic Ewing's sarcoma: an Intergroup Study. Natl. Cancer Inst. Monogr, (1981) 279-284
14. 14 Hayes, F. A., E. I. Thompson, L. Parvey, B. Rao, L. Kun, D. Parham, H. O. Hustu: Metastatic Ewing's sarcoma: remission induction and survival. J. Clin. Oncol. 5 (1987) 1199-1204
15. 15 Wessalowski, R., H. Jürgens, H. Bodenstein, W. Brandeis, P. Gutjahr, W. Havers, M. L. Huckels-Klasen, R. Kotz, J. Kühl, M. Salzer-Kuntschik, W. Tausch, P. A. Voûte, P. Weinel, K. Winkler, U. Göbel: [Results of treatment of primary metastatic Ewing sarcoma. A retrospective analysis of 48 patients] Behandlungsergebnisse beim primär metastasierten Ewing-Sarkom. Eine retrospektive Analyse von 48 Patienten. Klin. Pädiatr. 200 (1988) 253-260
16. 16 Cangir, A., T. J. Vietti, E. A. Gehan, E. O. Burgert, Jr., P. Thomas, M. Tefft, M. E. Nesbit, J. Kissane, D. Pritchard: Ewing's sarcoma metastatic at diagnosis. Results and comparisons of two intergroup Ewing's sarcoma studies. Cancer 66 (1990) 887-893
17. 17 Burdach, S., H. Jürgens, C. Peters, W. Nürnberger, C. Mauz-Körholz, D. Körholz, M. Paulussen, H. Pape, D. Dilloo, E. Koscielniak, H. Gadner, U. Göbel: Myeloablative radiochemotherapy and hematopoietic stem-cell rescue in poor-prognosis Ewing's sarcoma. J. Clin. Oncol. 11 (1993) 1482-1488
18. 18 Paulussen, M., G. Braun-Munzinger, S. Burdach, S. Deneke, J. Dunst, E. Fellinger, U. Göbel, U. Mittler, J. Treuner, P. A. Voûte, K. Winkler, H. Jürgens; [Results of treatment of primary exclusively pulmonary metastatic Ewing sarcoma. A retrospective analysis of 41 patients] Behandlungsergebnisse beim primär ausschliesslich pulmonal metastasierten Ewingsarkom. Eine retrospektive Analyse von 41 Patienten. Klin. Pädiatr. 205 (1993) 210-216
19. 19 Gasparini, M., F. Lombardi, E. Ballerini, L. Gandola, M. C. Gianni, M. Massimino, L. Rottoli, F. Fossati Bellani: Long-term outcome of patients with monostotic Ewing's sarcoma treated with combined modality. Med. Pediatr. Oncol. 23 (1994) 406-412
20. 20 Paulussen, M., S. Ahrens, A. W. Craft, J. Dunst, B. Fröhlich, S. Jabar, W. Winkelmann, S. Wissing, A. Zoubek, H. Jürgens, for EICESS: Ewing tumors with primary lung metastases: Survival analysis of 114 (European Intergroup) Ewing Sarcoma Studies patients. J. Clin. Oncol. 16 (1998) 3044-3052
21. 21 Mendenhall, C. M., R. B. Marcus, Jr., W. F. Enneking, D. S. Springfield, T. L. Thar, R. R. Million: The prognostic significance of soft tissue extension in Ewing's sarcoma. Cancer 51 (1983) 913-917
22. 22 Oberlin, O., C. Patte, F. Demeocq, M. J. Lacombe, M. Brunat Mentigny, M. C. Demaille, P. Tron, B. N'Guyen Bui, J. Lemerle: The response to initial chemotherapy as a prognostic factor in localized Ewing's sarcoma. Eur. J. Cancer. Clin. Oncol. 21 (1985) 463-467
23. 23 Göbel, V., H. Jürgens, G. Etspüler, H. Kemperdick, R. M. Jungblut, U. Stienen, U. Göbel: Prognostic significance of tumor volume in localized Ewing's sarcoma of bone in children and adolescents. J. Cancer. Res. Clin. Oncol. 113 (1987) 187-191
24. 24 Sauer, R., H. Jürgens, J. M. Burgers, J. Dunst, R., Hawlicek, J. Michaelis: Prognostic factors in the treatment of Ewing's sarcoma. The Ewing's Sarcoma Study Group of the German Society of Paediatric Oncology CESS 81. Radiother. Oncol. 10 (1987) 101-110
25. 25 Kushner, B. H., P. A. Meyers, W. L. Gerald, J. H. Healey, Q. M. La, P. Boland, N. Wollner, E. S. Casper, A. Aledo, G. Heller, et al: Very-high-dose short-term chemotherapy for poor-risk peripheral primitive neuroectodermal tumors, including Ewing's sarcoma, in children and young adults. J. Clin. Oncol. 13 (1995) 2796-2804
26. 26 Paulussen, M., S. Ahrens, S. Burdach, A. W. Craft, B. Dockhorn-Dworniczak, J. Dunst, B. Fröhlich, W. Winkelmann, A. Zoubek, H. Jürgens, on behalf of EICESS: Primary metastatic (stage IV) Ewing tumor. Survival analysis of 171 patients from the EICESS studies. Ann. Oncol. 9 (1998) 275-281
27. 27 Kaplan, E. L., P. Meier: Nonparametric estimation from incomplete observations. J. Am. Stat. Assoc. 53 (1958) 457-481
28. 28 Peto, R., M. C. Pike, P. Armitage, N. E. Breslow, D. R. Cox, S. V. Howard, N. Mantel, K. McPherson, J. Peto, P. G. Smith: Design and analysis of randomized clinical trials requiring prolonged observation of each patient. I. Introduction and design. Br. J. Cancer 34 (1976) 585-612
29. 29 Peto, R., M. C. Pike, P. Armitage, N. E. Breslow, D. R. Cox, S. V. Howard, N. Mantel, K. McPherson, J. Peto, P. G. Smith: Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples. Br. J. Cancer 35 (1977) 1-39
30. 30 Salzer-Kuntschik, M., G. Delling, G. Beron, R. Sigmund: Morphological grades of regression in osteosarcoma after polychemotherapy - study COSS 80. J. Cancer Res. Clin. Oncol. 106 Suppl. (1983) 21-24
31. 31 Schmidt, D., D. Harms: [Cooperative Ewing's Sarcoma Studies 81/86: pathologico-anatomic and immunohistochemical findings and differential diagnosis of Ewing sarcoma] CESS 81/86: Pathologisch-anatomische und immunhistochemische Befunde sowie Differentialdiagnose des Ewing-Sarkoms. Klin. Pädiatr. 200 (1988) 236-242
32. 32 Schmidt, D., D. Harms: The applicability of immunohistochemistry in the diagnosis and differential diagnosis of malignant soft tissue tumors. A reevaluation based on the material of the Kiel Pediatric Tumor Registry. Klin. Pädiatr. 202 (1990) 224-229
33. 33 Sandoval, C., W. H. Meyer, D. M. Parham, L. E. Kun, H. O. Hustu, X. Luo, C. B. Pratt: Outcome in 43 children presenting with metastatic Ewing sarcoma: the St Jude Children's Research Hospital experience, 1962 to 1992. Med. Pediatr. Oncol. 26 (1996) 180-185
34. 34 Fröhlich, B., S. Ahrens, S. Burdach, A. W. Craft, J. Dusnt, H. Pape, M. Paulussen, A. Zoubek, H. Jürgens, on behalf of EICESS: High-dose chemotherapy for primary metastatic or relapsed Ewing tumours: Outcome of 120 (EI)CESS patients. Annals of Hematology 277 (1998) S9-S9 (Abstr.)
35. 35 Fröhlich, B., S. Ahrens, A. W. Craft, J. Dunst, H. J. Laws, M. Paulussen, A. Zoubek, H. Jürgens: Ewing tumor patients with metastases to bone plus lung benefit from intensified treatment. Journal of Cancer Research and Clinical Oncology 124 (1998) R 128-R 128 (Abstr.)
36. 36 Picci, P., B. T. Rougraff, G. Bacci, J. R. Neff, L. Sangiorgi, A. Cazzola, N. Baldini, S. Ferrari, M. Mercuri, P. Ruggieri, et al: Prognostic significance of histopathologic response to chemotherapy in nonmetastatic Ewing's sarcoma of the extremities. J. Clin. Oncol. 11 (1993) 1763-1769
37. 37 Rossi, R., S. Danzebrink, D. Hillebrand, K. Linnenburger, K. Ullrich, H. Jurgens: Ifosfamide-induced subclinical nephrotoxicity and its potentiation hy cisplatinum. Med. Pediatr. Oncol. 22 (1994) 27-32
38. 38 Beck, J. D., K. Winkler, D. Niethammer, M. Brandis, H. Hertzberg, vonder-Hardt K., J. Greil, M. A. Überall, R., Rossi, A. Lamprecht-Dinnesen, et al.: [After-care of children and young adults surviving cancer. Initial recommendations by the late sequelae study group] Die Nachsorge der von einer Krebserkrankung geheilten Kinder und jungen Erwachsenen. Erste Empfehlungen der Arbeitsgemeinschaft Spätfolgen. Klin. Pädiatr. 207 (1995) 186-192
39. 39 Kushner, B. H., G. Heller, N. K. Cheung, N. Wollner, K. Kramer, D. Bajorin, T. Polyak, P. A, Meyers: High risk of leukemia after short-term dose-intensive chemotherapy in young patients with solid tumors. J. Clin. Oncol. 16 (1998) 3016-3020
40. 40 Smith, M. A., L. Rubinstein, R. S. Ungerleider: Therapy-related acute myeloid leukemia following treatment with epipodophyllotoxins: estimating the risks. Med. Pediatr. Oncol. 23 (1994) 86-98
41. 41 Smith, M. A., R. P. McCaffrey, J. E. Karp: The secondary leukemias: challenges and research directions. J. Natl. Cancer Inst. 88 (1996) 407-418
42. 42 Dunst, J., S. Ahrens, M. Paulussen, Ch. Rübe, W. Winkelmann, A. Zoubek, D. Harms, H. Jürgens: Second Malignancies after Treatment for Ewing's Sarcoma: A Report of the CESS-Studies. Int. J. Radiation Oncology Biol. Phys. 42 (1998) 379-384
43. 42 Pinkerton, R., J. E. Kingston, J. S. Malpas, T. J. McElwain: High Dose melphalan with Autologous Marrow Rescue in Ewing's sarcoma. European Cooperative Group for Bone Marrow Transplantation Meeting 1988 (1988) (Abstr.)
44. 44 Hartmann, O., O. Oberlin, F. Beaujean, L. Brugieres, D. Valteau, G. Vassal, J. Lemerle: [Role of high-dose chemotherapy followed by bone marrow autograft in the treatment of metastatic Ewing's sarcoma in children] Place de la chimiotherapie a hautes doses suivie d'autogreffe medullaire dans le traitement des sarcomes d'Ewing metastatiques de l'enfant. Bull. Cancer Paris 77 (1990) 181-187
45. 45 Ladenstein, R., C. Lasset, R. Pinkerton, J. M. Zucker, C. Peters, S. Burdach, N. Pardo, G. Dollorso, C. Coze, M. Buclon, et al: Impact of megatherapy in children with high-risk Ewing's tumours in complete remission: a report from the EBMT Solid Tumour Registry. Bone Marrow Transplant 15 (1995) 697-705
46. 46 Atra, A., J. S. Whelan, V. Calvagna, A. G. Shankar, S. Ashley, V. Shepherd, R. L. Souhami, C. R. Pinkerton: High-dose busulphan/melphalan with autologous stem cell rescue in Ewing's sarcoma. Bone Marrow Transplant 20 (1997) 843-846