Practical synthesis of 8α-amino-2,6-dimethylergoline: an industrial perspective

Organic Process Research and Development

Volumn 1, Issue 6, 1997, Pages 395-406

  Baenziger, M ^a   Mak, C P ^a   Muehle, H ^a   Nobs, F ^a   Prikoszovich, W ^a   Reber, J L ^a   Sunay, U ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0000073969     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op9700284     Document Type: Article

References (11)

1. Stoll, A.; Hofmann, A. In The Alkaloids; Manske, R. H. F., Homes, H. L., Eds.; Academic Press: New York, 1965; Vol. 8, p 772.
2. Ergolines are generally referred to as alkaloids having the basic structure (6aR)-trans-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-f,g]quinoline;ergolenes are dehydroergolines and differ in the position of the double bond (8,9 or 9,10); see: Ninomiya, I.; Kiguchi, T. In The Alkaloids; Brossi A., Ed.; Academic Press: New York, 1990; Vol. 38, p 14 and references cited therein.
3. Stoll, A.; Hofmann, A. Helv. Chim. Acta 1943, 26, 944. Stoll, W. A. Schweiz. Arch. Neural. Psychiatr. 1947, 60, 279. Hofmann, A. Die Mutterkornal-kaloide; F. Enke Verlag: Stuttgart, 1964; p 183. Hofmann, A. Die Geschichte des LSD 25 (The history of LSD 25). Triangel 1955, 2, 117.
4. Stoll, A.; Hofmann, A. Helv. Chim. Acta 1943, 26, 944. Stoll, W. A. Schweiz. Arch. Neural. Psychiatr. 1947, 60, 279. Hofmann, A. Die Mutterkornal-kaloide; F. Enke Verlag: Stuttgart, 1964; p 183. Hofmann, A. Die Geschichte des LSD 25 (The history of LSD 25). Triangel 1955, 2, 117.
5. Stoll, A.; Hofmann, A. Helv. Chim. Acta 1943, 26, 944. Stoll, W. A. Schweiz. Arch. Neural. Psychiatr. 1947, 60, 279. Hofmann, A. Die Mutterkornal-kaloide; F. Enke Verlag: Stuttgart, 1964; p 183. Hofmann, A. Die Geschichte des LSD 25 (The history of LSD 25). Triangel 1955, 2, 117.
6. Stoll, A.; Hofmann, A. Helv. Chim. Acta 1943, 26, 944. Stoll, W. A. Schweiz. Arch. Neural. Psychiatr. 1947, 60, 279. Hofmann, A. Die Mutterkornal-kaloide; F. Enke Verlag: Stuttgart, 1964; p 183. Hofmann, A. Die Geschichte des LSD 25 (The history of LSD 25). Triangel 1955, 2, 117.
7. Berde, B.; Stürmer, E. In Ergot Alkaloids and Related Compounds; Schield, H. B., Ed.; Springer Press: Berlin/Heidelberg/New York, 1978. Schardt, F.; Miskra, R. B. Ther. Ggw. 1982, 121, 26.
8. Berde, B.; Stürmer, E. In Ergot Alkaloids and Related Compounds; Schield, H. B., Ed.; Springer Press: Berlin/Heidelberg/New York, 1978. Schardt, F.; Miskra, R. B. Ther. Ggw. 1982, 121, 26.
9. Schneider, H. R.; Stadier, P. A.; Stütz, R; Troxler, F.; Seres, J. Experientia 1977, 33, 1412. Flückiger, F.; Wagner, H. R. Experientia 1968, 24, 1130. Kebabian, J. W.; Calne, D. B. Nature 1979, 277, 93.
10. Schneider, H. R.; Stadier, P. A.; Stütz, R; Troxler, F.; Seres, J. Experientia 1977, 33, 1412. Flückiger, F.; Wagner, H. R. Experientia 1968, 24, 1130. Kebabian, J. W.; Calne, D. B. Nature 1979, 277, 93.
11. Schneider, H. R.; Stadier, P. A.; Stütz, R; Troxler, F.; Seres, J. Experientia 1977, 33, 1412. Flückiger, F.; Wagner, H. R. Experientia 1968, 24, 1130. Kebabian, J. W.; Calne, D. B. Nature 1979, 277, 93.