An Improved Generator for the Production of 213Bi from 225Ac

Radiochimica Acta

Volumn 79, Issue 2, 1997, Pages 141-144

  Wu, Chuanchu ^a   Brechbiel, Martin W ^a   Gansow, Otto A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

213 Bi; 225Ac; Actinide; Generator; Radioimmunotherapy

Indexed keywords

EID: 0000072752     PISSN: 00338230     EISSN: None     Source Type: Journal    
DOI: 10.1524/ract.1997.79.2.141     Document Type: Article

References (14)

1. Humm, J. L., Chin, L. M.: A Model of Cell Inactivation by Alpha-Particle Internal Emitters. Radiat. Res. 134, 143 (1993).
2. Macklis, R. M., Kinsey, B. M., Kassis, A. I., Ferrara, J. L. M., Atcher, R. W., Mines, J. J., Coleman, C. N., Adelstein, S. J., Burakoff, S. J.: Radioimmunotherapy with Alpha-Particle-Emitting Immunoconjugates. Science 240, 1024 (1988).
3. Wilbur, S.: Potential use of α-emitting Radionuclides in the Treatment of Cancer. Antibody, Immunoconj. Radiopharm. 4, 85 (1991).
4. 224Ra. J. Radioanal. Nucl. Chem. Lett. 117, 155 (1987).
5. 224Ra. Appl. Radiat. Isot. 39, 283 (1988).
6. Huneke, R. B., Pippin, C. G., Squire, R. A., Brechbiel, M. W., Gansow, O. A., Strand, M.: Effective α-Particle-mediated Radioimmunotherapy of Murine Leukemia. Cancer Res. 52, 5818 (1992).
7. Geerlings, M. W.: Radionuclides for Radioimmunotherapy: Criteria for Selection. Intl. J. Biol. Markers 8, 180 (1993).
8. Geerlings, M. W., Kaspersen, F. M., Apostolidis, C., Van Der Hout, R.: The Feasibility of Ac-225 as a Source of α-Particles in Radioimmunotherapy. Nucl. Med. Commun. 14, 121 (1993).
9. Geerlings, M. W.: Radioimmunotherapy Using α-Particles Emission. Int. Patent WO 90/15625 (1990).
10. Pippin, C. G., Gansow, O. A., Brechbiel, M. W., Koch, L., Molinet, R., Van Geel, J., Apostolidis, C., Geerlings, M. W., Scheinberg, D. A.: Recovery of Bi-213 from an Ac-225 Cow: Application to the Radiolabeling of Antibodies with Bi-213. In: Chemists' Views of Imaging Centers (A. M. Emran, ed.) Plenum Press, New York 1995.
11. 212Bi Alpha-particle Emitter. J. Chem. Soc., Perkin Trans. 1, 1173 (1992).
12. Mirzadeh, S., Brechbiel, M. W., Atcher, R. W., Gansow, O. A.: Radiolabeling of Immunoproteins: Covalent Linkage of 2 - (4 - Isothiocyanatobenzyl) diethylenetriamine - pentaacetic Acid Ligands to Immunoglobulin. Bioconjugate Chem. 1, 59 (1990).
13. El Samad, O., Dalmasso, J., Barcl-Funel, G., Ardisson, G.: Fast radiochemical Separation and γ Spectroscopy of Short-lived Thallium Isotopes. Radiochim. Acta 62, 65 (1993).
14. 225Ac α-Decay. J. Radioanal. Nucl. Chem. Lett. 144, 387 (1990).