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Volumn 35, Issue 9, 1996, Pages 2637-2643

Photoinduced DNA Cleavage Reactions by Designed Analogues of Co(III)-Bleomycin: The Metalated Core Is the Primary Determinant of Sequence Specificity

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Indexed keywords


EID: 0000050862     PISSN: 00201669     EISSN: None     Source Type: Journal    
DOI: 10.1021/ic9503139     Document Type: Article
Times cited : (25)

References (36)
  • 23
    • 2742531665 scopus 로고    scopus 로고
    • note
    • 2+ moiety bound to the duplex and one with the same moiety free) in the form of doublings of H9 and HI protons (supporting information).
  • 27
  • 29
    • 2742544957 scopus 로고    scopus 로고
    • BLM carries a 2,4′-bithiazole in its DNA-binding domain although the ring system is connected to positively-charged amine tails that results in stronger DNA binding
    • BLM carries a 2,4′-bithiazole in its DNA-binding domain although the ring system is connected to positively-charged amine tails that results in stronger DNA binding.
  • 30
    • 85088230318 scopus 로고    scopus 로고
    • 15
    • 15
  • 33
    • 85088226509 scopus 로고    scopus 로고
    • note
    • 16 Clearly, the acridine ring of 6 intercalates into the base stack of 8 in a classical manner.
  • 34
    • 85088227722 scopus 로고    scopus 로고
    • 24
    • 24
  • 35
    • 2742554880 scopus 로고    scopus 로고
    • note
    • No doubling of peaks is observed when simpler analogues like 3-5 are added to 8. These complexes most possibly do not stay close to the helix for long time (rapid on-and-off situation), and hence the diastereomeric A-DNA and A-DNA complexes are not resolved in the NMR spectra of the analogue-DNA adducts.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.