Determining and understanding the control of flux: An illustration in submitochondrial particles of how to validate schemes of metabolic control

European Journal of Biochemistry

Volumn 264, Issue 2, 1999, Pages 427-433

  Moreno Sánchez, Rafael ^b   Bravo, Concepción ^c   Westerhoff, Hans V ^a  

^a BioCentrum Amsterdam   (Netherlands)

^b INSTITUTO NACIONAL DE CARDIOLOGÍA IGNACIO CHÁVEZ   (Mexico)

^c NONE

Author keywords

H+ leak; H+ ATPase; Metabolic control theory; Respiratory chain

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; CITRININ; CYANIDE; CYTOCHROME C OXIDASE; MALONIC ACID; PROTON; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; SUCCINATE DEHYDROGENASE; UBIQUINOL CYTOCHROME C REDUCTASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ELECTRON TRANSPORT; ENZYME ACTIVITY; HYDROLYSIS; LIVER MITOCHONDRION; METABOLIC REGULATION; MITOCHONDRIAL RESPIRATION; NONHUMAN; PRIORITY JOURNAL; PROTON TRANSPORT; RAT; RESPIRATORY CHAIN;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIMYCIN A; CYANIDES; ELECTRON TRANSPORT; ELECTRON TRANSPORT COMPLEX III; ELECTRON TRANSPORT COMPLEX IV; HYDROGEN-ION CONCENTRATION; KINETICS; MALONATES; MITOCHONDRIA, LIVER; OXYGEN CONSUMPTION; RATS; RATS, WISTAR; SUCCINATE DEHYDROGENASE; TEMPERATURE;

ANIMALIA;

EID: 0000047526     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1999.00621.x     Document Type: Article

References (38)

1. Fell, D.A. (1982) Metabolic control analysis: a survey of its theoretical and experimental development. Biochem. J. 286, 313-330.
2. Moreno-Sánchez, R. & Torres-Márquez, M.E. (1991) Control of oxidative phosphorylation in mitochondria, cells, and tissues. Inter. J. Biochem. 23, 1163-1174.
3. Brown, G.C. (1992) Control of respiration and ATP synthesis in mammalian mitochondria and cells. Biochem. J. 284, 1-13.
4. Heinrich, R. & Schuster, S. (1996) The Regulation of Cellular Systems. International Thomson Publishing Co, New York.
5. Fell, D. (1997) Understanding the Control of Metabolism. Portland Press, London, UK.
6. Groen, A.K., Wanders, R.J.A., Westerhoff, H.V., Van der Meer, R. & Tager, J.M. (1982) Quantification of the contribution of various steps to the control of mitochondrial respiration. J. Biol. Chem. 257, 2754-2757.
7. Gellerich, F.N., Bohnensack, R. & Kunz, W. (1983) Control of mitochondrial respiration. Biochim. Biophys. Acta 722, 381-391.
8. Baggetto, L., Gautheron, D.C. & Godinot, C. (1984) Effects of ATP on various steps controlling the rate of oxidative phosphorylation in newborn rat liver mitochondria. Arch. Biochem. Biophys. 232, 670-678,.
9. Doussiere, J., Ligeti, E., Brandolin, G. & Vignais, P.V. (1984) Control of oxidative phosphorylation in rat heart mitochondria. Biochim. Biophys. Acta 766, 492-500.
10. 2+ concentrations. J. Biol. Chem. 260, 4028-4034.
11. Moreno-Sánchez, R. (1985) Contribution of the translocator of adenine nucleotides and the ATP synthase to the control of oxidative phosphorylation and arsenylation in liver mitochondria. J. Biol. Chem. 260, 12554-12560.
12. Mazat, J.P., Bart, E.J., Rigoulet, M. & Guerin, B. (1986) Control of oxidative phosphorylation in yeast mitochondria: role of the phosphate carrier. Biochim. Biophys. Acta 849, 7-15.
13. H+ ratio. FEBS Lett. 233, 17-21.
14. Gellerich, F.N., Kunz, W.S. & Bohnensack, R. (1990) Estimation of flux control coefficients from inhibitor titrations by non-linear regression. FEBS Lett. 274, 167-170.
15. Moreno-Sánchez, R., Devars, S., López-Gómez, F.J., Uribe, A. & Corona, N. (1991) Distribution of control of oxidative phosphorylation in mitochondria oxidizing NAD-linked substrates. Biochim. Biophys. Acta 1060, 286-292.
16. García, C., Pardo, J.P. & Moreno-Sánchez, R. (1996) Control of oxidative phosphorylation supported by NAD-linked substrates in rat brain mitochondria. Biochem. Arch. 12, 157-176.
17. Small, R. (1993) Flux control coefficients determined by inhibitor titration: the design and analysis of experiments to minimize errors. Biochem. J. 296, 423-433.
18. Wisniewski, E., Kunz, W.S. & Gellerich, F.N. (1993) Phosphate affects the distribution of flux control among the enzymes of oxidative phosphorylation in rat skeletal muscle mitochondria. J. Biol. Chem. 268, 9343-9346.
19. Kacser, H. & Burns, J.A. (1973) The control of flux. Symposium Soc. Exptl. Biol. 27, 65-104.
20. Groen, A.K., Van Roermund. C.W.T., Vervoorn, R.C. & Tager. J.M. (1986) Control of gluconeogenesis in rat liver cells. Biochem. J. 237, 379-389.
21. Westerhoff, H.V., Plomp, P.J.A.M., Groen, A.K., Wanders, R.J.A., Bode, J.A. & Van Dam, K. (1987) On the origin of the limited control of mitochondrial respiration by the adenine nucleotide translocator. Arch. Biochem. Biophys. 257, 154-169.
22. Westerhoff, H.V., Plomp, P.J.A.M., Groen, A.K. & Wanders, R.J.A. (1987) Thermodynamics of the control of metabolism. Cell Biophys. 10, 239-267.
23. Westerhoff, H.V. & Van Dam, K. (1987) Thermodynamics and control of biological free-energy transduction. Elsevier, Amsterdam.
24. Brown, G.C., Hafner, R.P. & Brand, M.D. (1990) A 'top-down' approach to the determination of control coefficients in metabolic control theory. Eur. J. Biochem. 188, 321-325.
25. Brown, G.C., Lakin-Thomas, P.L. & Brand, M.D. (1990) Control of respiration and oxidative phosphorylation in isolated rat liver cells. Eur. J. Biochem. 192, 355-362.
26. Fell, D.A. & Sauro, H.M. (1985) Metabolic control and its analysis. Eur. J. Biochem. 148, 555-561.
27. Schuster, S., Kahn, D. & Westerhoff, H.V. (1993) Modular analysis of the control of complex metabolic pathways. Biophys. Chem. 48, 1-17.
28. Schuster, S., Kahn, D. & Westerhoff, H.V. (1995) Control analysis of metabolic systems consisting of uni- and/or multifunctional units. J. Biol. Syst. 3, 217-230.
29. Ainscow, E.K. & Brand, M.D. (1998) Control analysis of systems with reaction blocks that cross-talk. Biochim. Biophys. Acta 1366, 284-290.
30. Thayer, W.S. & Rubin, E. (1979) Effects of chronic ethanol intoxication on oxidative phosphorylation in rat liver submitochondrial particles. J. Biol. Chem. 254, 7717-7723.
31. +-ATPases: an improved fluorescent assay. Biochim. Biophys. Acta 1183, 161-170.
32. Singer, T.P., Kearney, E.B. & Kenney, W.C. (1973) Succinate dehydrogenase. Adv. Enzymol. 37, 189-272.
33. Dervartanian, D.V. & Veeger, C. (1964) Studies on succinate dehydrogenase. Biochim. Biophys. Acta 92, 233-247.
34. Letellier, T., Malgat, M. & Mazat, J.P. (1993) Control of oxidative phosphorylation in rat mucle mitochondria: implications for mitochondrial myopathies. Biochim. Biophys. Acta 1141, 58-64.
35. Rottenberg, H. & Lee, C.P. (1975) Energy dependent hydrogen ion accumulation in submitochondrial particles. Biochemistry 14, 2675-2680.
36. Nishimura, M., Ito, T. & Chance, B. (1962) Studies on bacterial photophosphorylation. Biochim. Biophys. Acta 59, 177-182.
37. Petronilli, V., Azzone, G.F. & Pietrobon, D. (1988) Analysis of mechanisms of free-energy coupling and uncoupling by inhibitor titrations: theory, computer modeling and experiments. Biochim. Biophys. Acta 932, 306-324.
38. Kholodenko, B.N., Lyubarev, A.E. & Kurganov, B.I. (1992) Control of the metabolic flux in a system with high enzyme concentrations and moiety-conserved cycles. Eur. J. Biochem. 210, 147-153.