Effect of regional angiotensin II infusion on the relationship between tumour blood flow and fluorouracil uptake in a liver metastasis animal model

European Journal of Cancer Part A

Volumn 32, Issue 9, 1996, Pages 1580-1584

  Dworkin, M J ^a   Zweit, J ^b   Carnochan, P ^b   Deehan, B ^b   Allen Mersh, T G ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^b ROYAL MARSDEN HOSPITAL   (United Kingdom)

Author keywords

Angiotensin II; Blood flow; Fluorouracil; Liver metastasis; Regional chemotherapy

Indexed keywords

ANGIOTENSIN; COPPER 64; FLUOROURACIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG UPTAKE; INTRAARTERIAL DRUG ADMINISTRATION; LIVER BLOOD FLOW; LIVER METASTASIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SARCOMA; TUMOR BLOOD FLOW;

EID: 0000046140     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/0959-8049(96)00169-4     Document Type: Article

References (22)

1. 1. Allen-Mersh TG. Improving survival after large bowel cancer: surgeons should look for the occult. Leader. Br Med J 1991, 303, 595-596.
2. 2. Advanced Colorectal Cancer Metaanalysis Project. Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: evidence in terms of response rate. J Clin Oncol 1992, 10, 896-903.
3. 3. Drewinko B, Yang LY, Ho DHW, et al. Treatment of cultured human colon carcinoma cells with fluorinated pyrimidines. Cancer 1980, 45, 1144-1158.
4. 4. Hyrniuk WM, Figueredo A, Goodyear M. Application of dose intensity to problems in chemotherapy of breast and colorectal cancer. Semin Oncol 1987, 4, 3-11.
5. 5. Ensminger WD, Rosowsky A, Raso V, et al. A clinical pharmacological evaluation of hepatic arterial infusions of 5-fluorodeoxyuridine and 5-fluorouracil. Cancer Res 1978, 38, 3784-3792.
6. 6. Dworkin MJ, Allen-Mersh TG. Regional infusion chemotherapy for colorectal hepatic metastases - where is it going? Cancer Treat Rev 1991, 18, 213-224.
7. 7. Allen-Mersh TG, Fordy C, Abrams K, Houghton J. Quality of life and survival with continuous hepatic-artery floxuridine infusion for colorectal liver metastases. Lancet 1994, 344, 1255-1260.
8. 8. Kemeny N, Cohen A, Bertino J, et al. Continuous intrahepatic infusion of floxuridine and leucovorin through an implantable pump for the treatment of hepatic metastases from colorectal carcinoma. Cancer 1989, 65, 2446-2450.
9. 9. Sigurdson ER, Ridge JA, Daly JM. Fluorodeoxyuridine uptake by human colorectal hepatic metastases after hepatic artery infusion. Surgery 1986, 100, 285-291.
10. 10. Cater DB, Adair HM, Grove CA. Effects of vasomotor drugs and mediators of the inflammatory reaction upon the oxygen tension of tumours and tumour blood supply. Br J Cancer 1966, 20, 504-516.
11. 11. Ackerman NB, Hechmer PA. The blood supply of experimental liver metastases. V. Increased tumour perfusion with epinephrine. Am J Surg 1980, 140, 625-631.
12. 12. Mathias CJ, Welch MA, Perry DJ, et al. Investigation of Cu-PTSM as a PET tracer for tumour blood flow. Int J Rad Appl Instrum 1991, 18, 807-811.
13. 13. Young H, Carnochan P, Zweit J, et al. Evaluation of copper(II)-pyruvaldehyde bis (N-4-methylthiosemicarbazone) for tissue blood flow measurement using a trapped tracer model. Eur J Nucl Med 1994, 21, 336-341.
14. 14. Green MA, Klippenstein DL, Tennison JR. Copper (II) bis (thiosemicarbazone) complexes as potential tracers for evaluation of cerebral and myocardial blood flow with PET. J Nucl Med 1988, 29, 1549-1557.
15. 15. Hemingway DM, Cooke TG, Grime SJ, Nott DM, Jenkins SA. Change in hepatic haemodynamics and hepatic perfusion index during the growth and development of hypovascular HSN sarcoma in rats. Br J Surg 1991, 78, 328-330.
16. 16. Burke D, Carnochan P, Allen-Mersh TG. Drug uptake is related to blood flow in a liver metastasis model. Br J Surg 1994, 81, 1808.
17. 17. Dworkin MJ, Carnochan P, Allen-Mersh TG. Vasoactive agents do not increase blood flow to liver but endothelin does produce a rise in tumour to liver blood flow ratio. Br J Surg 1992, 79, 1240 (Abstract).
18. 18. Dworkin MJ, Carnochan P, Allen-Mersh TG. Nitric oxide inhibition sustains vasopressin-induced vasoconstriction. Br J Cancer 1995, 71, 942-944.
19. 19. Carter R, Cooke TG, Hemingway D, McArdle CS, Angerson W. The combination of degradable starch microspheres and angiotensin II in the manipulation of drug delivery in an animal model of colorectal metastasis. Br J Cancer 1992, 65, 37-39.
20. 20. BMDP Statistical Software Manual. Volume 2. Dixon WJ, ed. University of California Press, Berkeley, 1990, 1253-1254.
21. 21. Goldberg JA, Murray T, Kerr DJ, et al. The use of angiotensin II as a potential method of targeting cytotoxic microspheres in patients with intrahepatic tumour. Br J Cancer 1991, 63, 308-310.
22. 22. Jain RK. Haemodynamic and transport barriers to the treatment of solid tumours. Int J Rad Biol 1991, 60, 85-100.