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85088669779
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note
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2, 0°). Other isonitriles Ib-f were similarly prepared in 61 to 82% overall yields from o-iodoformanilide by palladium-mediated coupling reactions.
-
-
-
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11
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33646757152
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-
note
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A typical experimental procedure is as follows: A solution of an isonitrile (0.85 mmole), n-Bu3SnH (0.93 mmole), and AIBN (0.04 mmole) in 5 ml of dry acetonitrile was heated at 100° for 1 hour in a tightly capped culture tube under an argon atmosphere. The reaction mixture was partitioned between 3 W HC1 and ether. After washing the ethereal layer with a saturated KF solution, the desired indole was separated by flash silica gel chromatography.
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-
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14
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0001688482
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The Stille coupling of l-SEM-2-tributylstannylindole with a variety of halides has recently been reported: G. Palmisano and M. Santagostino, Helv. Chim. Acta, 76, 2356 (1993).
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Perry, N.B.1
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[b] N. B. Perry, J. W. Blunt, M. H. G. Munro, T. Iliga and R. Sakai, J. Org. Chem., 53, 4127 (1988);
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Perry, N.B.1
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21
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33845281157
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J. W. Blunt, V. L. Calder, G. D. Fenwick, R. J. Lake, J. D. McCombs, M. H. G. Munro and N. B. Perry, J. Nat. Prod, 50, 290 (1987).
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22
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B. R. Copp, K. F. Fulton, N. B. Perry, J. W. Blunt and M. H. G. Munro, J. Org. Chem., 59, 8233 (1994).
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J. R. Henry, L. R. Marcin, M. C. Mclntosh, P. M. Scola, G. D. Harris Jr. and S. M. Weinreb, Tetrahedron Letters, 30, 5709 (1989).
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35
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0003543590
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Academic, New York, 1983, Chapter 13.
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For general synthesis of amines, see: S. R. Sandier and W. Karo, Organic Functional Group Preparations, 2nd Ed, Academic, New York, 1983, Chapter 13.
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Organic Functional Group Preparations, 2nd Ed
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Sandier, S.R.1
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