Evidence for Progression of Brain Structural Abnormalities in Schizophrenia: Beyond the Neurodevelopmental Model

Australian and New Zealand Journal of Psychiatry

Volumn 34, Issue , 2000, Pages S113-S126

  Velakoulis, Dennis ^a   Wood, Stephen J ^a   Mcgorry, Patrick D ^a   Pantelis, Christos ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

high risk; hippocampus; longitudinal; neurodegeneration; psychosis

Indexed keywords

BRAIN; CONGENITAL MALFORMATION; DIAGNOSTIC IMAGING; DISEASE COURSE; HEMISPHERIC DOMINANCE; HIPPOCAMPUS; HUMAN; NEUROPSYCHOLOGICAL TEST; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW; RISK FACTOR; SCHIZOPHRENIA;

BRAIN; DIAGNOSTIC IMAGING; DISEASE PROGRESSION; DOMINANCE, CEREBRAL; HIPPOCAMPUS; HUMANS; NEUROPSYCHOLOGICAL TESTS; RISK FACTORS; SCHIZOPHRENIA;

EID: 0000027857     PISSN: 00048674     EISSN: 14401614     Source Type: Journal    
DOI: 10.1080/000486700231     Document Type: Article

References (105)

1. Buchsbaum MS. The frontal lobes, basal ganglia, temporal lobes as sites for schizophrenia. Schizophrenia Bulletin 1990; 16:379–390.
2. Pantelis C, Barnes TR, Nelson HE. Is the concept of frontal-subcortical dementia relevant to schizophrenia? British Journal of Psychiatry 1992; 160:442–460.
3. Weinberger DR, Berman KF, Suddath RL, Torrey EF. Evidence of dysfunction of a prefrontal-limbic network in schizophrenia: an MRI and regional cerebral blood flow study of discordant monozygotic twins. American Journal of Psychiatry 1992; 149:890–897.
4. Gold JM, Harvey PD. Cognitive deficits in schizophrenia. Psychiatric Clinics of North America 1993; 16:295–312.
5. Weinberger DR. From neuropathology to neurodevelopment. Lancet 1995; 346:552–557.
6. Harrison PJ. The neuropathology of schizophrenia: a critical review of the data and their interpretation. Brain 1999; 122:593–624.
7. Woods BT. Is schizophrenia a progressive neurodevelopmental disorder? Toward a unitary pathogenetic mechanism. American Journal of Psychiatry 1998; 155:1661–1670.
8. Weinberger DR. Implications of normal brain development for the pathogenesis of schizophrenia. Archives of General Psychiatry 1987; 44:660–669.
9. Jones P, Murray RM. The genetics of schizophrenia is the genetics of neurodevelopment. British Journal of Psychiatry 1991; 158:615–623.
10. Murray RM. Neurodevelopmental schizophrenia: the rediscovery of dementia praecox. British Journal of Psychiatry. 1994; 165 (Suppl.):6–12.
11. Pantelis C. Overview. Towards a neuropsychology of schizophrenia. In: Pantelis C, Nelson HE, Barnes TR, eds. Schizophrenia: a neuropsychological perspective. London: Wiley, 1996:3–18.
12. Walker EF, Savoie T, Davis D. Neuromotor precursors of schizophrenia. Schizophrenia Bulletin 1994; 20:441–451.
13. Benes FM. Myelination of cortical-hippocampal relays during late adolcescence. Schizophrenia Bulletin 1989; 15:585–593.
14. Stevens JR. Abnormal reinnervation as a basis for schizophrenia: a hypothesis [published erratum appears in Archives of General Psychiatry 1992; 49:708] Archives of General Psychiatry 1992; 49:238–243.
15. Uno H, Eisele S, Sakai A et al. Neurotoxicity of glucocorticoids in the primate brain. Hormones and Behavior 1994; 28:336–348.
16. Lipska BK, Jaskiw GE, Weinberger DR. Postpubertal emergence of hyperresponsiveness to stress and to amphetamine after neonatal excitotoxic hippocampal damage: a potential animal model of schizophrenia. Neuropsychopharmacology 1993; 9:67–75.
17. Lawrie SM, Abukmeil SS. Brain abnormality in schizophrenia: a systematic and quantitative review of volumetric magnetic resonance imaging studies. British Journal of Psychiatry 1998; 172:110–120.
18. Nelson MD, Saykin AJ, Flashman LA, Riordan HJ. Hippocampal volume reduction in schizophrenia as assessed by magnetic resonance imaging: a meta-analytic study. Archives of General Psychiatry 1998; 55:433–440.
19. Wright IC, Rabe-Hesketh S, Woodruff PW, David AS, Murray RM, Bullmore ET. Meta-analysis of regional brain volumes in schizophrenia. American Journal of Psychiatry 2000; 157:16–25.
20. Papez JW. A proposed mechansim of emotion. Archives of Neurology and Psychiatry 1939; 38:725–743.
21. Mishkin M. A memory system in the monkey. Philosophical Transactions of the Royal Society of London 1982; 298:85–95.
22. Goldman-Rakic PS. Circuitry of primate prefrontal cortex and regulation of behaviour by representational memory. In: Plum F, ed. Handbook of physiology: the nervous system, vol. 5. Bethesda: American Physiological Society, 1987:373–417.
23. Nauta WJH, Feirtag M. Fundamental neuroanatomy. New York: W.H. Freeman, 1986.
24. Crosson B. Subcortical functions in language and memory. 1st edn. London: Guildford Press, 1992.
25. Alexander G, DeLong M, Strick P. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annual Review of Neuroscience 1986; 9:357–381.
26. Goldman-Rakic PS. Prefrontal cortical dysfunction in schizophrenia: the relevance of working memory. In: Carroll BJ, Barrett JE, eds. Psychopathology and the brain. New York: Raven Press, 1991.
27. DeLong MR. Primate models of movement disorders of basal ganglia origin. Trends in Neurosciences 1990; 13:281–285.
28. Robbins TW. The case for frontostriatal dysfunction in schizophrenia. Schizophrenia Bulletin 1990; 16:391–402.
29. Pantelis C, Brewer W. Neuropsychological and olfactory dysfunction in schizophrenia: relationship of frontal syndromes to syndromes of schizophrenia. Schizophrenia Research 1995; 17:35–45.
30. Slater E, Beard AW, Glithero E. The schizophrenia like psychoses of epilepsy. British Journal of Psychiatry 1963; 109:95–150.
31. Trimble MR. First-rank symptoms of Schneider. A new perspective? British Journal of Psychiatry 1990; 156:195–200.
32. Conlon P, Trimble MR, Rogers D. A study of epileptic psychosis using magnetic resonance imaging. British Journal of Psychiatry 1990; 156:231–235.
33. Bruton C, Stevens J, Frith CD. Epilepsy, psychosis and schizophrenia: clinical and neuropathologic correlations. Neurology 1994; 44:34–42.
34. Taylor DC. Factors influencing the occurrence of schizophrenia-like psychosis in patients with temporal lobe epilepsy. Psycholological Medicine 1975; 5:249–254.
35. Pantelis C, Barnes TRE. Drug strategies and treatment-resistant schizophrenia. Australian and New Zealand Journal of Psychiatry 1996; 30:20–37.
36. Moller H-J, von Zerssen D. Course and outcome of schizophrenia. In: Hirsch SR, Weinberger DR, eds. Schizophrenia. 1st edn. Oxford: Blackwell Science, 1995: 106–127.
37. Mesulam MM. Large-scale neurocognitive networks and distributed processing for attention, language, and memory. Annals of Neurology 1990; 28:597–613.
38. Frith CD, Done DJ. Towards a neuropsychology of schizophrenia. British Journal of Psychiatry 1988; 153:437–443.
39. Barber F, Pantelis C, Bodger S, Nelson HE. Intellectual functioning in schizophrenia: natural history. In: Pantelis C, Nelson HE, Barnes TR, eds. Schizophrenia: a neuropsychological perspective. London: Wiley, 1996:49–70.
40. Rund BR. A review of longitudinal studies of cognitive functions in schizophrenia patients. Schizophrenia Bulletin 1998; 24:425–435.
41. Hyde T, Nawroz S, Goldberg TE et al. Is there cognitive decline in schizophrenia? A cross-sectional study. British Journal of Psychiatry 1994; 164:494–500.
42. Bilder RM, Goldman RS, Robinson D et al. Neuropsychology of first-episode schizophrenia: initial characterization and clinical correlates. American Journal of Psychiatry 2000; 157:549–559.
43. Gold S, Arndt S, Nopoulos P, O'Leary DS, Andreasen NC. Longitudinal study of cognitive function in first-episode and recent-onset schizophrenia. American Journal of Psychiatry 1999; 156:1342–1348.
44. Hoff AL, Sakuma M, Wieneke M, Horon R, Kushner M, DeLisi LE. Longitudinal neuropsychological follow-up study of patients with first-episode schizophrenia. American Journal of Psychiatry 1999; 156:1336–1341.
45. Green MF, Marshall BDJ, Wirshing WC et al. Does risperidone improve verbal working memory in treatment-resistant schizophrenia? American Journal of Psychiatry 1997; 154:799–804.
46. Kern RS, Green MF, Marshall BDJ et al. Risperidone versus haloperidol on secondary memory: can newer medications aid learning? Schizophrenia Bulletin 1999; 25:223–232.
47. Meltzer HY, McGurk SR. The effects of clozapine, risperidone, and olanzapine on cognitive function in schizophrenia. Schizophrenia Bulletin 1999; 25:233–255.
48. Stevens JR. Neuropathology of schizophrenia. Archives of General Psychiatry 1982; 39:1131–1139.
49. Benes FM, Sorensen I, Bird ED. Reduced neuronal size in posterior hippocampus of schizophrenic patients. Schizophrenia Bulletin 1991; 17:597–608.
50. Rajkowska G, Selemon LD, Goldman-Rakic PS. Neuronal and glial somal size in the prefrontal cortex: a post-mortem morphometric study of schizophrenia and Huntington disease. Archives of General Psychiatry 1998; 55:215–224.
51. Pakkenberg B. Pronounced reduction of total neuron number in mediodorsal thalamic nucleus and nucleus accumbens in schizophrenics. Archives of General Psychiatry 1990; 47:1023–1028.
52. Keshavan MS, Anderson S, Pettegrew JW. Is schizophrenia due to excessive synaptic pruning in the prefrontal cortex? The Feinberg hypothesis revisited. Journal of Psychiatric Research 1994; 28:239–265.
53. Dell'Anna M, Geloso M, Draisci G, Luthman J. Transient changes in fos and GFAP immunoreactivity precede neuronal loss in the rat hippocampus following neonatal anoxia. Experimental Neurology 1995; 131:144–156.
54. Paus T, Zijdenbos A, Worsley K et al. Structural maturation of neural pathways in children and adolescents: an in vivo study. Science 1999; 283:1908–1911.
55. McKinney RA, Debanne D, Gähwiler BH, Thompson SM. Lesion-induced axonal sprouting and hyperexcitability in the hippocampus in vitro: Implications for the genesis of posttraumatic epilepsy. Nature Medicine 1997; 3:990–996.
56. Eriksson PS, Perfilieva E, Björk-Eriksson T et al. Neurogenesis in the adult human hippocampus. Nature Medicine 1998; 4:1313–1317.
57. Maguire EA, Gadian DG, Johnsrude IS et al. Navigation-related structural change in the hippocampi of taxi drivers. Proceedings of the National Academy of Science 2000; 97:4398–4403 (on-line).http://www.pnas.org/cgi/doi/10.1073/pnas.070039597.
58. Kraemer HC, Yesavage JA, Taylor JL, Kupfer D. How can we learn about developmental processes from cross-sectional studies, or can we? American Journal of Psychiatry 2000; 157:163–171.
59. Shelton RC, Weinberger DR. X-Ray computerized tomography studies in schizophrenia a review and synthesis. In: Nasrallah HA, Weinberger DR, eds. Handbook of schizophrenia, vol. 1: The neurology of schizophrenia. New York: Elsevier Science Publishers, 1986:207–250.
60. Johnstone EC, Owens DG, Bydder GM, Colter N, Crow TJ, Frith CD. The spectrum of structural brain changes in schizophrenia: age of onset as a predictor of cognitive and clinical impairments and their cerebral correlates. Psycholological Medicine 1989; 19:91–103.
61. Strakowski SM, Wilson DR, Tohen M, Woods BT, Douglass AW, Stoll AL. Structural brain abnormalities in 1st-episode mania. Biological Psychiatry 1993; 33:602–609.
62. Swayze VW, Andreasen NC, Alliger RJ, Ehrhardt JC, Yuh WT. Structural brain abnormalities in bipolar affective disorder. Ventricular enlargement and focal signal hyperintensities. Archives of General Psychiatry 1990; 47:1054–1059.
63. Coffey CE, Wilkinson WE, Weiner RD et al. Quantitative cerebral anatomy in depression. A controlled magnetic resonance imaging study. Archives of General Psychiatry 1993; 50:7–16.
64. Krishnan KR, Doraiswamy PM, Figiel GS et al. Hippocampal abnormalities in depression. Journal of Neuropsychiatry and Clinical Neuroscience 1991; 3:387–391.
65. Velakoulis D, Pantelis C, McGorry PD et al. Hippocampal volume in first-episode psychoses and chronic schizophrenia: a high-resolution magnetic resonance imaging study. Archives of General Psychiatry 1999; 56: 133–140.
66. Copolov D, Velakoulis D, McGorry PD et al. Neurobiological findings in prodromal and early phase schizophrenia. Brain Research Reviews 1999; 31:157–165.
67. Bullmore ET, Suckling J, Overmeyer S, Rabe-Hesketh S, Taylor E, Brammer M. Global, voxel and cluster tests, by theory and permutation for a difference between two groups of structural MR images of the brain. IEEE Transactions on Medical Imaging 1999; 18:32–42.
68. DeLisi LE, Hoff AL, Schwartz JE et al. Brain morphology in first-episode schizophrenic-like psychotic patients: a quantitative magnetic resonance imaging study. Biological Psychiatry 1991; 29:159–175.
69. Knoll IV JL, Garver DL, Ramberg JE, Kingsbury SJ, Croissant D, McDermott B. Heterogeneity of the psychoses: Is there a neurodegenerative psychosis? Schizophrenia Bulletin 1998; 24:365–379.
70. Yung AR, Phillips LJ, McGorry PD et al. Prediction of psychosis: a step towards indicated prevention of schizophrenia. British Journal of Psychiatry 1998; 172 (Suppl. 33):14–20.
71. Cannon T, Mednick SA, Parnas J, Schulsinger F, Praestholm J, Vestergaard A. Developmental brain abnormalities in the offspring of schizophrenic mothers I: contributions of genetic and perinatal factors. Archives of General Psychiatry 1993; 50:551–564.
72. Lawrie SM, Whalley H, Kestelman JN et al. Magnetic resonance imaging of brain in people at high risk of developing schizophrenia. Lancet 1999; 353:30–33.
73. Yung AR, Yuen HP, McGorry PD et al. Can we predict onset of first episode psychosis in a high risk group? International Clinical Psychopharmacology 1998; 13 (Suppl. 1): 23–30.
74. McGlashan T, Johannessen J. Early detection and intervention with schizophrenia: Rationale. Schizophrenia Bulletin 1996; 22:201–222.
75. Velakoulis D, Phillips LJ, McGorry PD et al. Larger left hippocapal volume predicts transition to psychosis in an ultra high-risk group. Schizophrenia Research 2000; 41:117.
76. Nasrallah HA, Olson SC, McCalley-Whitters M, Chapman S, Jacoby CG. Cerebral ventricular enlargement in schizophrenia: a preliminary follow-up study. Archives of General Psychiatry 1986; 43:157–159.
77. Vita A, Sacchetti E, Valvassori G, Cazzullo C. Brain morphology in schizophrenia: a 2- to 5-year CT scan follow-up study. Acta Psychiatrica Scandinavica 1988; 78:618–621.
78. Illowsky BP, Juliano DM, Bigelow LB, Weinberger DR. Stability of CT scan findings in schizophrenia: Results of an 8 year follow-up study. Journal of Neurology, Neurosurgery and Psychiatry 1988; 51:209–213.
79. Kemali D, Maj M, Galderisi S, Milici N, Salvati A. Ventricle-to-brain ratio in schizophrenia: a controlled follow-up study. Biological Psychiatry 1989; 26:753–756.
80. Woods BT, Yurgelun-Todd D, Benes FM, Frankenburg FR, Pope Jr HG, McSparren J. Progressive ventricular enlargement in schizophrenia: comparison to bipolar affective disorder and correlation with clinical course. Biological Psychiatry 1990; 27:341–352.
81. Sponheim SR, Iacono WG, Beiser M. Stability of ventricular size after the onset of psychosis in schizophrenia. Psychiatry Research: Neuroimaging 1991; 40:21–29.
82. Hoffman WF, Ballard L, Turner EH, Casey DE. Three-year follow-up of older schizophrenics: extrapyramidal syndromes, psychiatric symptoms, and ventricular brain ratio. Biological Psychiatry 1991; 30:913–926.
83. Degreef G, Ashtari M, Wu H, Borenstein M, Geisler S, Lieberman JA. Follow up MRI study in first episode schizophrenia. Schizophrenia Research 1991; 5:204–206.
84. DeLisi LE, Stritzke P, Riordan HJ et al. The timing of brain morphological changes in schizophrenia and their relationship to clinical outcome. Biological Psychiatry 1992; 31:241–254.
85. Jaskiw G, Juliano D, Goldberg TE, Hertzman M, Urow-Hammell E, Weinberger DR. Cerebral ventricular enlargement in schizophreniform disorder does not progress. A seven year follow-up study. Schizophrenia Research 1994; 14:23–28.
86. Vita A, Giobbio GM, Dieci M et al. Stability of cerebral ventricular size from the appearance of the first psychotic symptoms to the later diagnosis of schizophrenia. Biological Psychiatry 1994; 35:960–962.
87. DeLisi LE, Tew W, Xie S et al. A prospective follow-up study of brain morphology and cognition in first-episode schizophrenic patients: preliminary findings. Biological Psychiatry 1995; 38:349–360.
88. DeLisi LE, Sakuma M, Tew W, Kushner M, Hoff AL, Grimson R. Schizophrenia as a chronic active brain process: a study of progressive brain structural change subsequent to the onset of schizophrenia. Psychiatry Research 1997; 74:129–140.
89. Rapoport JL, Giedd JN, Kumra S et al. Childhood-onset schizophrenia: progressive ventricular change during adolescence. Archives of General Psychiatry 1997; 54:897–903.
90. Nair TR, Christensen JD, Kingsbury SJ, Kumar NG, Terry WM, Garver DL. Progression of cerebroventricular enlargement and the subtyping of schizophrenia. Psychiatry Research 1997; 74: 141–150.
91. Madsen A, Keiding N, Karle A, Esbjerg S, Hemmingsen R. Neuroleptics in progressive structural brain abnormalities in psychiatric illness. Lancet 1998; 352:784–785.
92. Davis KL, Buchsbaum MS, Shihabuddin L et al. Ventricular enlargement in poor-outcome schizophrenia. Biological Psychiatry 1998; 43:783–793.
93. Jacobsen L, Giedd JN, Castellanos FX et al. Progressive reduction of temporal lobe structures in childhood-onset schizophrenia. American Journal of Psychiatry 1998; 155:678–685.
94. Keshavan MS, Haas GL, Kahn CE et al. Superior temporal gyrus and the course of early schizophrenia: progressive, static, or reversible? Journal of Psychiatric Research 1998; 32:161–167.
95. Gur RE, Cowell P, Turetsky BI et al. A follow-up magnetic resonance imaging study of schizophrenia: relationship of neuroanatomical changes to clinical and neurobehavioural measures. Archives of General Psychiatry 1998; 55:145–152.
96. Giedd JN, Jeffries NO, Blumenthal J et al. Childhood onset schizophrenia: progressive brain changes during adolescence. Biological Psychiatry 1999; 46:892–898.
97. Rapoport JL, Giedd JN, Blumenthal J et al. Progressive cortical change during adolescence in childhood-onset schizophrenia: a longitudinal magnetic resonance imaging study. Archives of General Psychiatry 1999; 56:649–654.
98. Madsen A, Karle A, Rubin P, Cortsen M, Andersen H, Hemmingsen R. Progressive atrophy of the frontal lobes in first-episode schizophrenia: interaction with clinical course and neuroleptic treatment. Acta Psychiatrica Scandinavica 1999; 100:367–374.
99. McCarley RW, Hirayasu Y, Salisbury DF et al. Left posterior superior temporal gyrus: progressive gray matter volume reduction in schizophrenia. Schizophrenia Research 1999; 36:204–205.
100. Gunduz H, Zuffante P, Wu H et al. Longitudinal follow-up of superior temporal gyrus gray matter in first-episode schizophrenia. Schizophrenia Research 1999; 36:199.
101. DeLisi LE. Defining the course of brain structural change and plasticity in schizophrenia. Psychiatry Research: Neuroimaging 1999; 92:1–9.
102. Pantelis C, Velakoulis D, Suckling J et al. Left medial temporal volume reduction occurs during the transition from high-risk to first-episode psychosis. Schizophrenia Research 2000; 41:35.
103. Vance AL, Velakoulis D, Maruff P, Wood SJ, Desmond P, Pantelis C. Magnetic resonance spectroscopy and schizophrenia: what have we learnt? Australian and New Zealand Journal of Psychiatry 2000; 34:14–25.
104. McCarley RW, Wible CG, Frumin M, Hirayasu Y, Fischer IA, Shenton ME. MRI anatomy of schizophrenia. Biological Psychiatry 1999; 45:1085–1098.
105. Olney J, Farber N. Glutamate receptor dysfunction and schizophrenia. Archives of General Psychiatry 1995; 52:998–1007.